Kanesa ole Prostate: Abstract
O le kanesa ole Prostate (PCa) o loʻo avea pea ma mafuaʻaga o mafuaʻaga o le oti i aliʻi o Amerika ma o loʻo faʻaauau pea le siʻitia o le lalolagi atoa aemaise lava i atunuʻu o loʻo faʻaaoga e tamaloloa meaʻai o le Westest-style. Epidemiologic, preclinical ma falemaʻi suʻesuʻega fautua mai ai le ono gaioiga mo taumafaina o meaʻai i le mea na tupu ma le alualu i luma o le PCa. 'O lenei minireview maua mai ai se aotelega o talu ai nei lolomiina tusitusiga e faʻatatau i taumafa, meaʻai mea taua, meaʻai mamanu ma PCa tupu ma agaʻi i luma. O le maualalo ole gaʻo o loʻo iai, soya protein, omega-3 (w-3) gaʻo, green green, tamato ma tamato oloa ma le zyflamend na faʻaalia ai le folafolaina ile faʻaititia ole PCa tulaga lamatia poʻo le alualu i luma. O le maualuga faʻatumuina gaʻo gaʻo ma le maualuga? -Carotene tulaga ono faʻateleina lamatiaga. E mafai ona i ai se sootaga i le va o le folate, vitamini C, vitamini D ma le kalama ma le PCa. E ui lava i le le ogatasi ma le le mautinoa o sailiga, o le ono mafai ona avea ma matafaioi o taumafa i meaʻai mo le puipuia ma le togafitia o le PCa o loʻo folafola mai. O le tuʻufaʻatasia o mea aoga uma mo le PCa ono faʻaititia o le faʻaititia o se meaʻai soifua maloloina, atonu o se fautuaga lelei mo meaʻai. O lenei faʻataʻitaʻiga e aofia ai fua o fualaʻau ma fualaʻau mata, faʻaitiitia ai gaʻo gaʻoina, gaʻo atoa ma gaʻo faʻatumuina, ma faʻaititia ai kuka vela. O isi suʻesuʻega fuafuaina ma le faaeteete e taua.
Upu Taua: Meaʻai, Kanesa o le Prostate, Meaʻai, Mamanu Taʻitaʻi, Soifua Maloloina, Puipuia, Togafitiga, Meaʻai, Meaʻai Faʻatonu, Vaʻai
Mataupu
Faatomuaga: Kanesa ole Prostate
O le kanesa o le Prostate (PCa) o le kanesa lona lua lea e masani ona maua i aliʻi, ma le lata i le miliona tala fou na maua i le lalolagi atoa i tausaga taʻitasi [1], e tusa ma le ono taimi le maualuga na aʻafia ai i Sisifo nai lo atunuʻu e le o Sisifo. Meaʻai, ituaiga olaga, siʻosiʻomaga ma kenera mea o loʻo faʻataʻitaʻia e faia se sao i nei 'eseʻesega. O lenei iloiloga e faʻatauaina i le lata molimau o le ono avea o meaʻai meaʻai luga o PCa ma aofia ai faʻamaʻi epidemiologic ma faʻataʻitaʻi faʻataʻitaʻi faʻamaoniga mo le aʻafiaga o polotini, gaʻo, gaʻo, gaʻo, alafua, fualaʻau, isi meaʻai, meaʻai atoa ma faʻataʻitaʻi i mea ai a PCa. atinae ma / pe alualu i luma. Faʻamatalaga mai meta-auiliiliga poʻo lelei-fuafuaina faʻasolosolo faʻataʻitaʻiga ma lumanaʻi suʻesuʻega o loʻo faʻamamafaina i lenei iloiloga. E tatau ona maitauina o suʻesuʻega o meaʻai o meaʻai poʻo meaʻai ma kanesa e masani ona faʻatapulaʻaina i tapulaʻa eseese ma faʻapea ona faʻafaigata ai le faʻamatalaina o iʻuga. Mo se faʻataʻitaʻiga, pe a fuafuaina se suʻesuʻega e suʻesuʻeina le aʻafiaga o le aofaʻi o gaʻo, o le suia o le gaʻo o le puta, e mautinoa lava le suia ai o le polotini ma / poʻo le gaʻo, ma ono suia ai foʻi le faʻaaogaina o isi mea aoga. O lona iʻuga, e faigata ona faʻaalia le aafiaga e suia ai naʻo le faʻaaogaina o gaʻo. I se faʻaopopoga, o le aʻafiaga o macronutrients e ono aʻafia ai vaega o le aofaʻi atoatoa ma le ituaiga o macronutrients faʻaumatia. O itu uma e ono ono aʻafia ai le amataina o le kanesa ma / pe atinaʻe tutoʻatasi, ae e le o taimi uma e iloga ai i suʻesuʻega. E ui o lenei mataupu na toe iloiloina talu ai nei [2], ona o le tele o tusitusiga fou i luga o le autu, o se toefaʻaleleia iloiloga o loʻo faʻaalia iinei ma se aotelega laulau e saunia mo se vave faʻasino (Laulau 1).
Nutrients Carbohydrates Tuuina mai le talitonuga faapea o le inisalini o se tuputupu aʻe vaega mo PCa, ua manatu e faʻapea o le faʻaitiitia o gaʻo o le suka ma faʻapea o le tuʻuina i lalo o le serum insulin e ono faʻatelegeseina ai le tuputupu aʻe o le PCa [3]. Ioe, i meaola faʻataʻitaʻi, a le o le gaʻo-gaʻo o le ketogenic diet (NCKD) [4,5] poʻo le diet low-carbohydrate (20% kcal e pei o gaʻo) o loʻo i ai ni aafiaga lelei i le faifai lemu o le faʻatupulaia o le tuma prostate [6,7]. I suʻesuʻega a tagata, na maua ai ile tasi suʻesuʻega o le maualuga ole taumafa o meaʻai na faamamaina na fesoʻotaʻi ma le tele ole aʻafiaga ole PCa [7]. I se faʻaopopoga i le aofaʻi o gaʻo, o ituaiga gaʻo o loʻo ono aʻafia ai le PCa ae o suʻesuʻega e le talitonuina. O le ono mafai ona faʻaititia le PCa lamatiaga ma alualu i luma ala i le aʻafia o gaʻo o le gaʻo o le tino o loʻo suʻesuʻeina ma Metformin. Metformin faʻaititia le PCa sela faʻateleina ma tuai ai le alualu i luma i vitro ma i vivo, faʻatulagaina [8-10] ma faʻaititia faʻalavelave faʻafitauli ma maliu i tagata [11-13]. Lua toʻatasi lima faʻataʻitaʻi faʻataʻitaʻi falemaʻi na faʻaalia foi le aoga o metformin i le aʻafia ai faʻailoga o le PCa faʻateleina ma le alualu i luma [14,15]. Peitaʻi, o isi suʻesuʻega o faʻataʻitaʻiga e leʻo lagolagoina le aʻafiaga o le metformin i le toe tupu poʻo le faʻalavelave i le PCa [16-22]. E ui i le malosiaga e faʻaititia ai le aofaʻi poʻo le faigofie o mea ai o loʻo aoga ile puleaina ole PCa, o molimau e le maua mai faʻataʻitaʻiga faʻataʻitaʻia (RCT). Lua faʻataʻitaʻiga faʻataʻitaʻi o loʻo faaauau pea suʻesuʻeina le aʻafiaga o le maualalo-gaʻo o meaʻai (pe a ma le 5% kcal) i luga o le PSA taimi faʻaluaina i le va o tagata PCa faʻasolosolo radial prostatectomy (NCT01763944) ma luga o le glycemia tali i tagata mamaʻi amataina androgen faʻafitauli togafitiga (ADT) ( NCT00932672). O sailiga mai nei tofotofoga o le a faʻamalamalamaina ai le aʻafiaga o le gaʻo o le gaʻo i luga o faʻailoga o le alualu i luma o le PCa ma le matafaioi o le faʻaititia o le gaʻo o le gaʻo i le faʻatamaia o aʻafiaga o le ADT.
porotini
Ole tulaga lelei ole polotini mo le lelei atoatoa ole soifua maloloina poʻo le soifua maloloina ole prostate e le manino. E ui i le lauiloa o le maualalo o meaʻai o le karbate e maualuga ai le polotini, talu ai nei na suʻesuʻeina ai e le suʻesuʻeina e faapea, o le maualalo o le polotini o loʻo i ai, e fesoʻotaʻi ma le maualalo o le aʻafiaga o le kanesa ma le soifua maloloina atoa o aliʻi e 65 tausaga le matutua. Faatasi ai ma tamaloloa matutua nai lo 65, maualalo porotini taumafaina na fesoʻotaʻi ma le maualuga lamatiaga mo kanesa ma le aofai o le olaga nei. I meaola faʻataʻitaʻi le fua i le va ole polotini ma le gaʻo oona na afaina ai le soifua maloloina cardiometabolic, matua ma le ola umi [23]. O le matafaioi o meaʻai polotini ma le polotini i gaʻo karate i le PCa atinaʻe ma le alualu i luma manaʻomia nisi suʻesuʻega.
Proteins e Faʻavae i Meaola
O le suʻesuʻeina o polotini i meaʻai, pei o itu uma o le science science, e mafai ona luʻi. Mo se faʻataʻitaʻiga, o aano o manu, o se mafuaʻaga lea o polotini i taumafataga i Sisifo, e le gata i le polotini, ae faapena foi i gaʻo, kolisi, minerale ma isi mea aoga. O le aofaʻi o nei meaʻai e aofia ai gaʻo gaʻo e ono eseese mai le tasi aano o manu i le isi. O suʻesuʻega talu ai i le tagata na faʻaalia ai o le taumafaina o moa e leai ni paʻu, lea e paʻu maualalo i le cholesterol ma gaʻo totoa nai lo le tele o aano mumu, e leʻi fesoʻotaʻi ma le toe tupu poʻo le alualu i luma o PCa [25]. Ae ui i lea, o le taumafaina o moa tao na faʻafesoʻotaʻiina faʻatasi ma le PCa maoaʻe [26,27], aʻo le vela o le aano mumu na fesoʻotaʻi ma le faʻateleina o le PCa tulaga lamatia [26,27]. I le taimi nei, faʻafefea ona sauniuni meaʻai e mafai ona toe fesuiaʻi lona aʻafiaga i le PCa lamatiaga ma le alualu i luma. I le aotelega, o taumafa iʻa e mafai ona fesoʻotaʻi ma le faʻaititia o le PCa maliu, ae o le vevela vevela iʻa kuka ono fesoasoani i PCa carcinogenesis [28]. O lea la, e ono fautuaina e faʻaʻai iʻa i taimi uma ae o le vevela o le kuka e tatau ona teu lelei.
Protein e faavae i le susu
O leisi mafuaʻaga masani protein o susu meaʻai, e pei o susu, sisi ma yogurt. O suʻesuʻega talu ai na faʻaalia ai o le susu na faʻateleina ai le tele o aʻafiaga o le PCa ae le o le malosi o le PCa [29,30]. I se faʻaopopoga, uma susu uma ma maualalo-gaʻo susu taumafaina na lipotia e le faʻalauteleina pe tolopo PCa alualu i luma [29,31]. I le Fomaʻi Soifua Maloloina tulitatao vasega ma 21,660 tamaloloa, o le aofaʻi o susu taumafaina na maua e fesoʻotaʻi ma le faʻateleina PCa faʻataʻitaʻi [32]. A faʻapitoa, o le maualalo o le gaʻo poʻo le susu susu faʻateleina maualalo vasega PCa, ae o le susu atoa faʻateleina lamatia PCa lamatia. E ui o le sao vaega (s) o oloa gaosi susu o loʻo faʻataʻitaʻia nei asosi e le o iloa, o le maualuga faʻatulagaina o gaʻo gaʻo ma kalasii ono aofia ai. O se suʻega suʻesuʻega o tamaloloa e 1798 na faʻaalia ai o le susu susu na fesoʻotaʻi lelei ma le serum IGF-1 [33] tulaga e ono faʻaosofia ai le amataina poʻo le alualu i luma o le PCa. O le mea lea, o loʻo manaʻomia nisi suʻesuʻega e faʻamanino ai le sootaga ile va ole susu ma PCa. E le lava faʻamatalaga e tuʻuina mai ai fautuaga faʻapitoa e fesoʻotaʻi ma susu poʻo susu susu ma PCa lamatiaga pe alualu i luma.
Polotini-Faʻavae Polotini
O soya ma soy-based oloa e mauʻoa i polotini ma filoestrogens e ono faʻafaigofieina PCa puipuia, ae o lana matafaioi i PCa e le manino. I se suʻesuʻega i isumu, o le taumafaina o soy oloa na fesoʻotaʻi ma le faʻaititia o le hepatic aromatase, 5? -Reductase, faʻaaliga o androgen receptor ma ana tulafono faʻatulafonoina, FOXA1, urogenital tract mamafa ma PCa tumo alualu i luma [34]. Talu ai nei o le faʻataʻitaʻia o le 177 tamaloloa ma faʻamaʻi tele le lamatiaga ina ua maeʻa prostatectomy mataʻutia na maua ai o le soy protein supplementation mo le lua tausaga e leai se aafiaga i le aʻafia o le PCa toe tupu [35]. E ui lava o epidemiological ma muaʻi falemaʻi suʻesuʻega [36,37] lagolagoina se ono gaioiga mo soy / soy isoflavones i le PCa lamatiaga faʻaititia poʻo le alualu i luma, o se meta-auiliiliga na le maua ai taua taua o soy faʻaaogaina i le PSA tulaga, feusuaʻiga hormone-noatia ai globulin, testosterone, maua fua testosterone, estradiol pe dihydrotestolone [38]. O le isi RCT i tagata mamaʻi ao le i mauaina le prostatectomy e leai foi se aafiaga o le soy isoflavone supa e oʻo atu i le ono vaiaso i luga o le PSA, serum aofaʻi testosterone, maua fua testosterone, aofaʻi estrogen, estradiol po o le aofaʻi o le kolesterol [39]. Talu ai o le tele o RCTs 'ua faʻatautaia na laiti ma puʻupuʻu, e manaʻomia ai nisi suʻesuʻega.
Tele suʻesuʻega na faʻaauau pea ona suʻesuʻe le muamua isoflavone i soy, genistein, ma lona aʻafiaga i le PCa. O le gafatia mo le genistein i inihibit PCa cell detachment, osofaʻiga ma metastasis ua lipotia [40]. Genistein mafai ona suia le faʻafouina o le suka ma le suka transporter (GLUT) faʻaaliga i PCa sela [41], pe faʻaaogaina lona anti-tuma aafiaga e ala i lalo faʻatonutonuina tele microRNAs [42]. O suʻesuʻega e faʻaaoga ai sela tuma ma manu, o loʻo fautua mai ai o le genistein e mafai ona tauva ma poloka endogenous estrogens mai le fusifusia i le estrogen receptor, ma taofia ai le faʻateleina o sela, tuputupu aʻe, ma faʻatupuina le fevaevaeaʻi, aemaise ai, o le genistein e ono taofia ai le teteʻa o sela, gaosia o protease, osofaʻiga o sela ma faʻapea puipuia metastasis [36,40,43]. Peitaʻi, e leʻo fesoʻotaʻi ma tulaga o le plasma poʻo le urinary genistein ma le PCa aʻafiaga i faʻatonuga suʻesuʻe mataupu [44,45]. I le vaega 2 placebo-pulea RCT ma 47 tamaloloa, faʻaopoopoga o le 30 mg genistein mo le tolu i le ono vaiaso faʻateteleina le faʻaititia o androgen-fesoʻotaʻi faʻailoga o PCa alualu i luma [46]. I se faʻaopopoga, genistein ono aoga i le faʻaleleia o le cabazitaxel chemotherapy i le metastatic castration-resistant PCa [37]. O faʻataʻitaʻi faʻapitoa e manaʻomia le toe suʻesuʻeina o le vaega o le soy ma soy isoflavones mo le PCa puipuia poʻo togafitiga. O se faʻamatalaga mautinoa e uiga i le faʻaaogaina o polotini mo le puipuia mai PCa poʻo togafitiga e le o maua.
gaʻo
Suʻesuʻega suʻesuʻega iloiloina gaʻo taumafaina ma PCa tulaga lamatia po o le alualu i luma e feteenai. Uma le aofaʻi atoatoa aiai [47] o meaʻai gaʻo ma le fesoʻotaʻiga gaʻo gaʻoa ono mafai tutoʻatasi fesoʻotaʻi ma PCa amataga ma / poʻo le alualu i luma. E ui o suʻesuʻega o meaola e faʻaalia ai o le faʻaititia o gaʻo o meaʻai i le tino e faʻatelegese ai le tuputupu aʻe o le tumo [48-50] ma le maualuga o gaʻo o meaʻai, aemaise ai o le gaʻo o le paʻu ma le suauʻu sana e faʻateleina ai le alualu i luma o le PCa [51], o faʻamatalaga a le tagata e tau le tumau ai. Suʻesuʻega faʻataʻitaʻiga ma suʻesuʻega faʻataʻitaʻi ua faʻaalia mai e leai se fesoʻotaʻiga i le va o le aofaʻi o le taumafaina o gaʻo ma le PCa tulaga lamatia [52-55] poʻo se faʻafesoʻotaʻiga le lelei i le va o le lololo taumafaina ma le ola PCa, ae maise lava i aliʻi e maua i le lotoifale PCa [47]. I se faʻaopopoga, o se suʻega suʻesuʻega na faʻaalia ai o le faʻaaogaina o le gaʻo ua faʻaalia o le pasene o le aofaʻi o le aofaʻi o kalori na fesoʻotaʻi lelei ma PSA tulaga i le 13,594 tamaloloa e aunoa ma le PCa [56]. Ona o nei feteʻenaʻiga faʻamaumauga, e ono mafai o le ituaiga o gaʻoa acid [56] nai lo le aofaʻi aofaʻi ono avea se taua tele i PCa atinaʻe ma alualu i luma. O se suʻesuʻega na maua ai le faʻatumuina o gaʻo gaʻo i le plasma e fesoʻotaʻi lelei ma le PCa i se tulaga faʻataʻitaʻi e 14,514 aliʻi o le Melbourne Collaborative Cohort Study [57]. I se faʻaopopoga, o le isi suʻesuʻega na maua ai o le 'ai o le tele o laʻau-faʻavae gaʻo na fesoʻotaʻi ma le faʻaititia o le PCa lamatiaga [58]. O nei suʻesuʻega e lagolagoina le taimi nei meaʻai taiala o le 'ai o laʻititi manu-faʻavae gaʻo ma sili atu laʻau faʻavae laʻau.
O faʻamatalaga e faʻatatau i le omega-6 (w-6) ma le omega-3 (w-3) polyunsaturated fatty acid (PUFA) taumafaina ma le PCa lamatiaga o loʻo feteʻenaʻi foʻi. E ui o loʻo iai faʻamatalaga e lagolago ai se fesoʻotaʻiga i le va o le faʻateleina o le w-6 PUFA o loʻo taumafaina (e tele lava ina maua mai i le suauʻu sana) ma le aʻafiaga o le PCa [57,59] maualuga, ae leʻo faʻamaumauga uma e lagolagoina lena sootaga [60]. O le mea moni, o le sili atu polyunsaturated gaʻo faʻaaogaina na fesoʻotaʻi ma le maualalo uma mafua mafuaʻaga feoti i totonu o aliʻi ma nonmetastatic PCa i le Soifua Maloloina Tomai Faʻapitoa suʻesuʻega [58]. Ole metotia faʻafesoʻotaʻi fesoʻotaʻi w-6 PUFAs ma PCa lamatiaga o le liua o le arachidonic acid (w-6 PUFA) i eicosanoids (prostaglandin E-2, hydroxyeicosatetraenoic acid ma epoxyeicosatrienoic acid) e tau atu i le fulafula ma sela faʻaolaola [61]. I se isi itu, o w-3 PUFAs, o loʻo maua faʻapitoa i iʻa malulu vai suavai, ono faʻatelegeseina le tuputupu ae o PCa e ala i le tele o auala [61-63]. I se suʻesuʻega o tamaloloa e 48 e maualalo le lamatiaga o le PCa i lalo o le mataʻituina o le mataʻituina, toe fai le biopsy i le ono masina na faʻaalia ai o le prostate tissue w-3 fatty acid, aemaise ai le eicosapentaenoic acid (EPA), e ono puipuia mai le faʻagaioia o PCa [64]. In vitro ma manu suʻesuʻega suʻesuʻega o le w-3 PUFA e faʻaosoina ai anti-inflammatory, pro-apoptotic, antiproliferative ma anti-angiogenic auala [65,66]. E le gata i lea, o se isumu suʻesuʻega faʻatusatusaina ituaiga eseese o gaʻo maua na o le iʻa suauʻu taumafa (o lona uiga, omega-3 faʻavae taumafa) faʻatelegese PCa tuputupu ae faʻatatau i isi gaʻo gaʻo [67]. E tusa ai ma faʻamaumauga a le tagata, o le vaega II o le faʻataʻitaʻiina o faʻataʻitaʻiga na faʻaalia ai o se meaʻai maualalo le gaʻo ma le w-3 faʻaopoopoga fa i le ono vaiaso a o lumanaʻi le tele o le prostatectomy na faʻaititia ai le faʻateleina o le PCa ma le faʻasolosolo o le taʻamilosaga o sela (CCP) togi [62,68]. O le maualalo o le gaʻo o le iʻa gaʻo iʻa na mafua ai le faʻaititia o le 15 (S) - hydroxyeicosatetraenoic acid maualuga ma tuʻuina i lalo le togi CCP e faʻatatau i taumafataga i Sisifo [69]. O aoga aoga o omega-3 fatty acid mai iʻa o loʻo lagolagoina e tusi faʻamaʻi o le epidemiological e faʻaalia ai o le w-3 fatty acid na faʻaaoga na fesoʻotaʻi faʻafesoʻotaʻi ma PCa lamatiaga [70,71]. E ui i le folafolaga o le omega-3 fatty acid, e leʻo suʻesuʻega uma. Faʻaopopoina 2 g alpha-linolenic acid (ALA) i le aso mo 40 masina i 1,622 tamaloloa ma PSA <4 ng / ml e leʻi suia la latou PSA [72]. Ae ui i lea, o le isi suʻesuʻega na maua ai o le maualuga toto serum n-3 PUFA ma le docosapentaenoic acid (DPA) na fesoʻotaʻi ma le faʻaititia o le aofaʻi o le PCa, ae o le maualuga o le serum EPA ma le docosahexaenoic acid (DHA) na ono fesoʻotaʻi ma le faʻateleina o le maualuga maualuga togi PCa [73] . O isi suʻesuʻega e manaʻomia ia malamalama lelei ai i le matafaioi a le omega-3 PUFA i le PCa puipuia poʻo togafitiga.
Cholesterol
O le tele o suʻesuʻega aʻo leʻi faia le falemaʻi ua faʻaalia ai o le faʻaputuputuina o le kolisi e fesoasoani i le alualu i luma o PCa [74-76]. Na fautuaina e faapea o le maualuga kolisi i Lin et al. BMC Faʻafomaʻi (2015) 13: 3 Itulau 5 o le 15 taamilosaga ono avea ma se tulaga lamatia mafuaʻaga mo mautu tuma, muamua lava i le faʻamalosia o le gaosia kolisi, ala faʻafefeteina [77] ma intratumoral steroidogenesis [78]. E tusa ai ma se suʻesuʻega talu ai nei ma le 2,408 tamaloloa ua atofaina mo le biopsy, o le serum cholesterol sa tutoatasi lava ma le valoʻaga o le PCa lamatiaga [79]. O gatasi ma mea na maua e le kolisi, o le faʻaaogaina o le toto tuʻuina i lalo o fualaʻau statin post radical prostatectomy (RP) na matua fesoʻotaʻi ma le faʻaitiitia o aʻafiaga o le biochemical toe tupu i 1,146 radical prostatectomy tagata mamaʻi [80]. O le isi suʻesuʻega na faʻaalia foi o statins e ono faʻaititia ai le PCa i le tuʻuina i lalo o le alualu i luma [81]. E ui lava e leʻi faʻamautuina le masini, ae o suʻesuʻega talu ai nei na faʻaalia ai foi, o le maualalo o le maualuga o le lipoprotein (HDL) cholesterol level na fesoʻotaʻi ma le maualuga o le aʻafiaga o le PCa ma, o le mea lea, o le maualuga o le HDL na puipuia ai [81-84]. Nei sailiiliga lagolagoina le manatu o le fatu-soifua maloloina meaʻai faʻasolosolo e maualalo le kolisi ono faʻamanuiaina foi prostate soifua maloloina.
Vitamini & Minerale
Lenei o le a tatou iloiloina ai lata mai faʻamatalaga luga vitamini A, B laʻasaga, C, D, E, ma K ma selenium. I le lua tele falemaʻi tofotofoga: o le Carotene ma Retinol Malosiaga Faʻataʻitaʻiga (CARET; PCa o se tulaga lua taunuʻuga) ma le National Institutes o le Soifua Maloloina-Amerika Association o tagata litaea (NIH-AARP) Diet ma Soifua Maloloina faamoemoe potopotoga suʻesuʻega, tele multivitamin faʻaopopoga sa fesoʻotaʻi ma le maualuga lamatiaga o le atiaʻe malosi PCa, aemaise lava i latou o loʻo aveina tagata taʻitasi? -carotene supa [85,86]. Faʻapena foi, maualuga serum? -Carotene tulaga na fesoʻotaʻi ma le maualuga lamatiaga mo PCa i 997 Finnish tamaloloa i le Kuopio Ischemic Heart Disease Risk Factor cohort [87]. Ae peitaʻi, e leʻo maua le? -Carotene supplement e aʻafia ai lamatiaga mo le oti PCa i le taimi o togafitiga [88], poʻo le suʻesuʻeina o le faʻalapotopotoga faʻapitoa a Danimaka o 26,856 tamaloloa [89]. O le faʻasalalauina o le retinol e leʻi fesoʻotaʻi foʻi ma le aʻafiaga o le PCa i se suʻesuʻega tele o le case control [90]. O le mea lea, o le fesoʻotaʻiga i le va vitamini A ma PCa e le o manino.
O faʻamaoniga tuusao e faʻapea mai ai o le faʻateʻaina o le folate e ono faʻateteʻitia ai le tuputupu aʻe o le tumo, aʻo le faʻaopopoga e leai se aoga i le tuputupu aʻe poʻo le alualu i luma, ae mafai ona taitai saʻo atu i suiga o le epigenetic e ala i le faʻateleina o le DNA methylation [91]. Lua faʻataʻitaʻiga suʻesuʻe na faʻaalia foi o le faʻasalalauina o le folate level na fesoʻotaʻi lelei ma le tele o aʻafiaga o le PCa [92,93], ae o meaʻai poʻo supplemental folate e leai se aʻafiaga o le PCa tulaga lamatia [94] i se suʻega suʻesuʻega ma 58,279 tamaloloa i Netherlands [ 95] ma se faʻataʻitaʻiga control control i Italia ma Suisalani [96]. O le mea moni, o se tasi suʻesuʻega o se vaega o tamaloloa o loʻo aʻafia i le radical prostatectomy i le tele o Veterans Administration i le salafa o le US, na faʻaalia foi o le maualuga o le serum folate level na fesoʻotaʻi ma le PSA maualalo ma, o le mea lea, o le maualalo o le aʻafiaga o le biochemical toilalo [97]. Le isi suʻesuʻega faʻaaogaina faʻamaumauga mai le 2007 i le 2010 National Health ma taumafa Suʻesuʻega Suʻesuʻega na faʻaalia ai o le maualuga o le folate tulaga e ono puipuia mai le maualuga o le tulaga PSA i le 3,293 tamaloloa, 40-tausaga le matutua pe sili atu, e aunoa ma le faʻamaonia PCa [98]. Na fautuaina e mafai e le folate ona taʻalo lua vaega i le prostate carcinogenesis ma, o le mea lea, o le faigata laʻasaga i le va o le folate ma le PCa o loʻo faʻatali atili i ai suʻesuʻega [99].
E ui lava i le aoga o le vaitamini C (ascorbic acid) e avea o se vailaʻau oona i le vailaʻau oona, o faʻataʻitaʻiga e suʻesuʻeina ai le taumafaina o meaʻai poʻo le faʻaopopoga o le vaitamini C, e toʻaitiiti lava. O le RCT na faʻaalia e leai se aoga o le vaitamini C faʻaaogaina i PCa tulaga lamatia [89]. E le gata i lea, o le vaitamini C i le maualuga o vailaʻau e mafai ona avea ma pro-oxidant nai lo le antioksidant, e faʻafaigataina ai le suʻesuʻeina o faʻamatalaga ma le faʻamatalaina o uiga.
O le muamua aoga ituaiga o vaitamini D, 1,25 dihydroxyvitamin D3 (calcitriol) fesoasoani i le lelei ponaivi fausiaina, faʻatosina eseʻesega o nisi sela puipuia, ma taofia auala pro-patu, pei o le faʻateleina ma angiogenesis, ma ua fautuaina e manuia PCa lamatiaga [100]; ae ui i lea, o sailiga e faʻaauau pea ona le mautinoa. Talu ai nei suesuega na maua ai o le faateleina o le serum vitamini tulaga na fesootai ma faaitiitia PCa tulaga lamatia [101,102]. E le gata i lea, o le faʻaopopoina o le vailaʻau D e ono faʻatelegeseina ai le alualu i luma ole PCa pe faʻaosofia ai foi le apoptosis i PCa sela [103-105]. Ae ui i lea, o isi suʻesuʻega, na lipotia mai a leai se afaina o le vailaʻau D faʻaopopo i le PSA [106] pe leai se aʻafiaga o le tulaga o le vaitamini D i le PCa tulaga lamatia [107,108]. O nisi o suʻesuʻega na lipotia mai ma le le faʻamalieina e faapea, o le maualalo o le tulaga o le vaitamini D na fesoʻotaʻi ma le tulaga maualalo o le PCa i aliʻi matutua [109], poʻo le maualuga o le vailaʻau o le vitamini D na fesoʻotaʻi ma se aʻafiaga maualuga o le PCa [110,111]. O se suʻesuʻega na fautuaina ai foi o le U foliga faʻafesoʻotaʻiga ono i ai i le va o le vaitamini D tulaga ma le PCa ma le sili atu le lelei o faʻasalalauina vitamini D mo PCa puipuia atonu e vaapiapi [112]. E ogatusa lea ma mea na maua mo isi mea aoga o le tele o meaʻai e ono le lelei i taimi uma.
O se suʻesuʻega talu ai nei na faʻaalia ai o le fesoʻotaʻiga i le va o vaitamini D ma PCa na faʻatulagaina e le vitamini D-fusifusia polotini [113] ia atonu na faʻamatalaina faʻamalamalamaina mea na maua muamua le saʻo. E le gata i lea, o se suʻesuʻega faʻapitoa e suʻesuʻe ai le fesoʻotaʻiga i le va o le Vitamini D receptor (VDR) polymorphisms (BsmI ma le FokI) ma le PCa lamatiaga lipotia leai se sootaga ma PCa tulaga lamatia [114]. Ole mea lea, ole vaega ole vaitamini D ile PCa e tumau pea le le malamalama.
I se tele tele faʻataʻitaʻiga faʻataʻitaʻi ma le aofaʻi o 14,641 US aliʻi fomaʻi? 50-tausaga le matua, tagata na mauaina soʻona mauaina 400 IU o vitamini E i isi aso uma mo le atoa uiga o 10.3 (13.8) tausaga. Vitamini E faʻaopopoga e leai se taimi lata mai pe umi se aʻafiaga i le aʻafiaga o le aofaʻi o kanesa poʻo le PCa [115]. Ae ui i lea, o se feololo o fualaʻau o vailaʻau E faʻaopopoga (50 mg pe tusa ma le 75 IU) na mafua ai le maualalo PCa lamatiaga i le 29,133 Finnish male ulaula ulaula [116]. Ole tele o faʻataʻitaʻiga suʻesuʻega fautua mai ai ole vitamini E e tuai ai le tuputupu aʻe o le tumo, ona o le taofiofia o le DNA synthesia ma le faʻaosoina o auala faʻaapopoti [117]. O le mea e leaga ai, o suʻesuʻega a tagata na le lava le lagolagoina. Lua suʻesuʻega suʻesuʻega (le Kanesa Faʻataʻitaʻiga Suʻesuʻega II Nutrisi Cohort ma le NIH-AARP Diet ma le Soifua Maloloina Suesuega) na faʻaalia e leai se fesoʻotaʻiga i le va vitamini E faʻaopopoga ma PCa tulaga lamatia [118,119]. Peitai, o le maualuga maualuga serum? -Tocopherol ae le o le? -Tocopherol level na fesoʻotaʻi ma le faʻaititia o le aʻafia o le PCa [120,121] ma le faʻafesoʻotaʻiga e mafai ona toe fesuiaʻi e fesuiaʻiga o ituaiga i vailaʻau E fesoʻotaʻi genes [122]. I se isi itu, o se faʻataʻitaʻiga e leʻi fuafuaina, o le Selenium ma le Vitamini E Faʻafomaʻi Puipui Faʻataʻitaʻiga (SELECT), faʻaalia vitamini E faʻaopopoga matua faʻateleina faateleina PCa tulaga lamatia [123] ma o le maualuga plasma? -Tocopherol tulaga ono fesoʻotaʻi ma selenium faʻaopoopoga e faʻateleina maualuga vasega PCa tulaga lamatia [124]. O lenei sailiga e ogatasi ma le suʻesuʻega o mataupu e 1,739 mataupu ma le 3,117 faʻatonutonu na faʻaalia ai le maualuga o le suka i le PCa i latou e maualalo le selenium tulaga ae leʻo i latou e maualuga le selenium tulaga [125]. O le mea lea, sili atu suʻesuʻega e manaʻomia e suʻesuʻe ai le fesoʻotaʻiga i le va o vaitamini E ma PCa ma le fualaʻau aʻafiaga ma fegalegaleaiga ma isi meaʻai e tatau ona mafaufauina.
Vitamini K na faʻataʻitaʻia e fesoasoani e puipuia le PCa i le faʻaititia o le bioavailable calcium. O faʻataʻitaʻiga suʻesuʻega faʻaalia ai le tuʻufaʻatasia o vaitamini C ma le K o loʻo iai le antitumor gaioiga malosi i vitro ma avea o chemo- ma radiosensitizers i vivo [126]. I le taimi nei, e toʻaitiiti suʻesuʻega na suʻesuʻeina lenei mea, e ui o le tasi suʻesuʻega na faʻaaogaina ai le European Prospective Investigation i le Kanesa ma le Taumafa (EPIC) -O Heidelberg cohort na maua se fesuiaʻiga sootaga i le va o vaitamini K (pei menaquinones) faʻaaogaina ma PCa tupu [127]. Laititi e leai ni faʻataʻitaʻiga suʻesuʻega na faia e suʻesuʻe ai le taua o le calcium ma le PCa. Faʻataʻitaʻiga ma meta-auiliiliga fautuaina faʻateleina pe faʻaititia le PCa aʻafiaga ma le faʻateleina o le calcium taumafaina, ae o isi fautua mai leai faʻatasi [128,129]. O le isi suʻesuʻega o loʻo taʻu mai ai le asosi e pei o le'U'-foliga, o le maualalo o le maualuga o le calcium poʻo le faʻaopopoga e fesoʻotaʻi ma PCa [130].
Selenium, i leisi itu, ua faʻataʻitaʻia e puipuia ai le PCa. A o in vitro suʻesuʻega na fautuaina ai o le selenium na taofia ai le angiogenesis ma le faʻateleina a o faʻamalosia le apoptosis [131], o iʻuga mai le SELECT e leai se aoga o le selenium naʻo ia poʻo le tuʻufaʻatasia ma le vaitamini E mo PCa chemoprevention [123]. E le gata i lea, o le selenium supplementation e leʻi faʻamanuiaina i tamaloloa e maualalo le tulaga o le selenium ae na faʻateleina le ono maua o le maualuga o le PCa i aliʻi e maualuga le selenium tulaga i se potopoto filifilia e 1,739 mataupu ma maualuga-grade (Gleason 7-10) PCa ma 3,117 faʻatonutonu [ 125]. O se suʻesuʻega Netherlands Cohort Study, na aofia ai 58,279 tamaloloa, 55 i le 69-tausaga le matua, na faʻaalia foi o le toenail selenium na fesoʻotaʻi ma le faʻaititia o le faʻaititia o le alualu i luma PCa [132]. O isi suʻesuʻega e manaʻomia e faʻamanino ai le matafaioi o le selenium ma le PCa.
Meaola oona
Faʻatasi ai ma vaitamini ma minerale [2], o loʻo i ai i totonu o vailaʻau ni vailaʻau oona ma ono ono tetee atu i le kanesa. Masani lava e le o manaʻomia taua tuʻufaʻatasia, phytochemicals i ai antioxidant ma aneti-afaina meatotino.
Silibinin o se polyphenolic flavonoid e maua i fatu o le susu laʻau. Na faʻaalia i le vitro ma le ola e faʻaoso ai le tuputupu aʻe PCa e ala i le faʻatatauina o le faʻaolaola o le tupuolaola o le toto (EGFR), IGF-1 receptor (IGF-1R), ma auala faaniukilia-kappa B (NF-kB) ala [133,134]. O se suʻesuʻega talu ai nei na faʻaalia ai o le silibinin atonu e aoga ile puipuia ole PCa ile taofia o le TGF? 2 expression ma cancerassociated fibroblast (CAF)-pei biomarkers i le tagata prostate stromal cells [135]. O le mea lea, silibinin o se sui tauva folafolaina o se PCa chemopreventive sooupu o loʻo faʻatali nisi suʻesuʻega.
O le Curcumin e faʻaaogaina o meaʻai faʻaopoopo i Asia ma avea ma vailaʻau faʻafomaʻi mo le fulafula [136]. In vitro, curcumin taofia le pro-inflammatory protein NF-? B ao faʻamalosia apoptosis e ala i le faʻateleina faʻaaliga o proapoptotic genes [137]. In vivo, curcumin slows PCa tuputupu ae i isumu aʻo faʻamalosia tino tuma i chemo- ma radiotherapies [136]; ae ui i lea, leai se faʻamasinoga a le tagata na suʻesuʻeina lona aʻafiaga i le PCa.
rimoni
O le paʻu ma fualaʻau o rimoni ma walnuts e mauoa i ellagitannins (punicalagins). O nei fualaʻau e vave lava ona faʻaletinoina i le gaioiga o ellagic acid e le gut flora [138]. O faʻataʻitaʻiga faʻataʻitaʻi faʻaalia ai ellagitannins taofiofia le faʻateleina ole PCa ma angiogenesis i lalo ole hypoxic tulaga ma faʻatosina apoptosis [137,138]. I suʻega faʻasolosolo i tamaloloa ma le siʻitia o le PSA i le maeʻa ai o togafitiga muamua, sua o le rimoni poʻo le POMx, o se faʻatau mai rimoni o loʻo avanoa faʻapisinisi, na faʻateleina ai le taimi faʻaluaina o le PSA e faʻatatau i laina amata [139,140], e ui lava e leai ni faʻataʻitaʻiga na aofia ai le vaega placebo. O loʻo talia iʻuga mai se placebo RCT o loʻo faamoemoe e faʻaaoga ai ni vaega o le rimoni i aliʻi ma le siisii i luga ole PSA. Ae ui i lea, i totonu o le placebo faʻataʻitaʻia faʻataʻitaʻiga, lua fualaʻau o le POMx i aso uma mo le oʻo i le fa vaiaso a o le i oʻo mai i le radical prostatectomy e leai se aʻafiaga i le tuma pathology poʻo le oxidative stress poʻo se isi lava tuma e faʻataʻitaʻia [141].
Tea Green
Green tea o loʻo iai le aofaʻi o polyphenols e faʻaaogaina ai vailaʻau e aofia ai catechins, pei o epigallocatechin gallate (EGCG), epigallocatechin (EGC), (?) - epicatechin-3-gallate (ECG) ma le (?) - epicatechin. O faʻataʻitaʻiga suʻesuʻega fautua mai EGCG taofia le tuputupu aʻe PCa, faʻamalosia intrinsic ma extrinsic apoptotic ala ma faʻaititia pupuga e ala i le taofiofia NFkB [137]. E le gata i lea, o vailaʻau o le EGCG e 25 i le 100 taimi e sili atu lona malosi nai lo vitamini C ma le E [131]. I se faʻataʻitaʻiga preprostatectomy faʻasolosolo faʻataʻitaʻia, o tamaloloa na inu pia lauti lanumeamata Lin et al. BMC Faʻafomaʻi (2015) 13: 3 Itulau 7 o le 15 aʻo leʻi faia le taotoga na faʻateleina le maualuga o le green tea polyphenols i totonu o a latou prostate tissue [142]. I se tamai faʻamaoniga-o faʻataʻitaʻiga faʻataʻitaʻiga ma 60 tamaloloa, i aso taʻitasi faʻaopopoina o le 600 mg green tea catechin upu faʻaititia faʻaititia PCa afaina e 90% (3% faʻatusatusa 30% i le placebo kulupu) [143]. O le isi tamaʻi faʻataʻitaʻiga na faʻaalia foi o le EGCG faʻaopopoga na mafua ai le faʻaititia tele o le PSA, tuputupu ae o le hepatocyte ma le faʻatupulaia o le endothelial vaega i aliʻi ma PCa [144]. O nei suʻesuʻega faʻailoa mai o le green green polyphenols e ono tuʻu ai i lalo le PCa ma faʻaititia ai le alualu i luma o le PCa ae e manaʻomia le tele o suʻesuʻega e faʻamaonia ai ma faʻamanino lana auala [137,143,145].
Resveratrol
E ui o le tele o vitro suʻesuʻega fautua mai resveratrol taofia le tuputupu aʻe PCa [146-148], resveratrol taofia le tuputupu ae tuma i nisi [137] ae le o manu uma faʻataʻitaʻi [149], atonu ona o le utiuti bioavailability [150,151]. I le taimi nei, e leai ni falemaʻi faʻataʻitaʻi suʻesuʻeina le puipuiga poʻo togafitiga togafitiga o resveratrol luga PCa.
Zyflamend
O le Zyflamend o se vailaʻau faʻafefeteina o vailaʻau na faʻaalia e faʻaititia ai le alualu i luma o le PCa e ala i le tuʻuina i lalo o le faʻailoga o faʻailoga e aofia ai le PAKT, PSA, histone deacetylases ma le androgen receptor i meaola manu ma laina laina o PCa [152-154]. E ui lava i lona malosi e tetee atu i le kanesa [155], e toaitiiti lava suʻesuʻega na faia i tagata [156,157]. I le tatalaina-igoa Phase I faʻataʻitaʻiga o 23 tagata mamaʻi ma maualuga-vasega prostatic intraepithelial neoplasia, Zyflamend toʻatasi pe o faatasi ma isi meaʻai supa mo le 18 masina faʻaititia le lamatiaga mo le atiaʻe PCa [156]. Tele RCTs i tagata e manaʻomia e faʻamaonia ai le aoga ma le faʻaogaina o lenei vailaʻau.
Isi Meaʻai Atoa Fualaʻau & Fualaʻau
Fualaʻau ma fualaʻau o loʻo avea ma oa tele o vitamini, minerals ma fitokimia. Ole tele o suʻesuʻega ole faʻamaʻi na maua ai le feʻaveaʻi o sootaga ile va o fualaʻau ma fualaʻau fai sua [158], ma le faʻaaogaina o fualaʻau ma fualaʻau ole PCa [159,160]. Allium fualaʻau, pei o kaliki, lulu, chives, ma bawang, o loʻo iai le tele o sulfurous phytochemicals na fautuaina e faʻalauteleina le puipuiga o le tino, taofiofia le tuputupu aʻe o sela, faʻataʻitaʻi le faʻaalia o androgen-responsive genes ma faʻatosina apoptosis [161]. E ui lava o le numera o lolomiga suʻesuʻega e faʻatapulaʻaina, o faʻamatalaga muamua ma faʻamaʻi o le epidemiologic o loʻo fautua mai ai o le faʻaaogaina o fualaʻau fualaʻau e mafai ona puipuia faasaga ile PCa, ae maise lava faʻamaʻi tuʻufaʻatasi [162]. O se faʻataʻitaʻiga le faʻataʻitaʻia ma 199 tamaloloa na maua ai foi o le palu faʻatasi o le rimoni, ti lanumeamata, broccoli ma le lega na matua faʻaititia ai le fua o le siʻitia o le PSA i aliʻi ma PCa [163].
Tomato & Tomato Oloa
E tele suʻesuʻega na suʻesuʻeina le fesoʻotaʻiga i le va o tamato ma tamato oloa ma PCa ae o mea na maua e le mautinoa. O le antioxidant lycopene, e mauoa i tamato, na suʻesuʻeina faʻapitoa foʻi mo lona aʻafiaga ile PCa. In vitro, lycopene taofi le taamilosaga sela i le tele o laina sela PCa ma faʻaititia le IGF-1 faʻailo e ala i le faʻaosofia o IGF-1 fusifusia polotini [131]. E ui o nisi o suʻesuʻega o meaola na maua ai le lycopene e faʻatelegese ai le tuputupu aʻe o le PCa [164] pe faʻaititia ai le sela o le epaʻi i le vaega o le amataga, faʻalauiloa ma le alualu i luma [165], e lua suʻesuʻega na maua ai ni feteʻenaʻiga i le va o tamato faapipii ma le lycopene [166,167]. O suʻesuʻega a le tagata na maua ai le maualuga o le taumafaina o le lycopene [168,169] poʻo le maualuga o le maualuga o le serum na fesoʻotaʻi ma le maualalo o le PCa tulaga lamatia [170], ae o isi e le i ai [171,172]. Prostatic lycopene concentrate lalo o le 1 ng / mg faitotoʻa na fesoʻotaʻi ma PCa i le ono masina tulitatao biopsy (P = 0.003) [173]. Lua taimi puʻupuʻu preprostatectomy tofotofoga faʻaaogaina tamato sosi poʻo lycopene faʻaopoopoga faʻaalia lycopene aveina i prostate aano ma antioxidant ma ono ono faʻatamaia anticancer aafiaga [174,175]. E ui o le tele o faʻataʻitaʻi faʻataʻitaʻi na fautuaina ai se fesuiaʻiga o sootaga i le va o le faʻaopoopoga o le lycopene, o le tulaga o le PSA ma le faʻaititia o faʻamaʻi o le kanesa [171,176], e leai ni faʻataʻitaʻiga tetele na faʻataʻitaʻia le taua o le lycopene poʻo le tamato oloa i le PCa puipuia poʻo togafitiga.
kofe
Kofe aofia ai caffeine ma le tele o le faʻailoaina phenolic compound e mafai ona avea o ni antioxidants. O suʻesuʻega o le Epidemiological o loʻo fautua mai ai, o se soʻotaga le lelei i le va o le taumafaina o le kofe ma le PCa, e tele lava ina maua i faʻamaʻi alualu i luma pe faʻamaʻi oti foi, ma o mea na maua e tutoʻatasi mai le mataupu o le caffeine [177,178]. E ui lava o le tele o faʻamaʻi epidemiological [179-182] na le maua ai se fesoʻotaʻiga i le va o le taumafaina o le kofe ma le PCa, ae o le lata mai ai o le suʻesuʻeina o suʻesuʻega faʻamaonia na faʻapea o le taumafaina o le kofe e ono faʻaititia ai le PCa tulaga lamatia [183]. O le ono mafai (s) ma auala (s) aʻafia e le o iloa ae ono aofia ai vailaʻau oona, anti-inflammatory aafiaga, kulukose ma le inisalini metabolism, ma ono aʻafia i IGF-I ma faʻasalalauina feusuaiga homone.
Mamanu Meaʻai
E ui lava o le tele o mea taua e tasi poʻo meaʻai na suʻesuʻeina mo latou aʻafiaga pe fesoʻotaʻi ma PCa tulaga lamatia poʻo le alualu i luma, o iʻuga na tele lava ina le talitonuina. O se mafuaʻaga mafuaʻaga mo le le ogatasi o le mea moni o le aʻafiaga o le tasi mea paleni poʻo meaʻai mea ono ono laʻititi e mafai ona iloa. I se faʻaopopoga, o meaʻai masani ai o loʻo iai i meaʻai e tele lava ina faʻafesoʻotaʻi ma ono feoaʻi ma isi, ma, aʻafia ai le aʻafiaga o le PCa. O le mea lea, o le faʻataʻitaʻiga o meaʻai taumafa na mauaina le faʻateleina Lin et al. BMC Faʻafomaʻi (2015) 13: 3 Itulau 8 o le 15 fiafia ae o faʻataʻitaʻiga sa faʻatapulaʻaina ma o loʻo iai nei faʻaiuga e le talitonuina. I le kulupu o 293,464 tamaloloa, o le maualuga o taumafa, e pei ona faʻailoa mai e le Healthy Eating Index (HEI), na fesoʻotaʻi ma le maualalo o aʻafiaga o le aofaʻi o le PCa tulaga lamatia [70]. O le taumafataga a le Metitirani, e maualuga i fualaʻau, suauʻu olive, gaʻo oona, meaʻai manogi ma vailaʻau faʻasaina, e fautuaina pea i tagata mamaʻi mo le puipuia o maʻi cardiovascular ma lapoʻa [184], ma ono faʻaali folafola i le PCa puipuiga [185]. Iʻa ma le omega-3 fatty acid taumafaina i le Metitirani faʻataʻitaʻiga sa tele ma fesuiaʻi fesoʻotaʻi ma lamatiaga PCa lamatia. I se faʻaopopoga, o le tausisi i le taumafataga a le Metitirani pe a maeʻa le faʻamaoniga o le le-metastatic PCa na fesoʻotaʻi ma le maualalo o le aofaʻi o tagata na maliliu [186]. A o se itu i Sisifo o loʻo maualuga ai ni meaʻai mumu, aano o manufasi, iʻa falai, chips, susu susu maualuga ma falaoa papaʻe, na fesoʻotaʻi ma se aʻafiaga maualuga mo PCa [187].
E le gata i lea, o atunuʻu Asia e maualuga le taumafaina o omega-3 PUFA, soy ma green tea-based phytochemicals, e i ai le maualalo ole PCa e faʻasaga i atunuʻu o loʻo taumafaina le'Western-style diet [188]. Ae ui i lea, e le o suʻesuʻega uma [189-191] lagolagoina se fesoʻotaʻiga i le va o nisi o taumafataga faʻataʻitaʻi ma lamatiaga o le PCa. E ono mafai ona faʻapea o metotia na faʻaaogaina e faʻailoa ai le faiga o meaʻai, e ono le maua uma ai meaʻai e fesoʻotaʻi ma le PCa. A le o lea, o laʻasaga masani o meaʻai e ono aofia ai vaega aoga uma ma faʻamaʻi e mafua ai le soʻotaga faʻaleaʻoaʻoga. E manaʻomia le tele o suʻesuʻega e faʻaauau ai le sailiga o meaʻai e tuʻufaʻatasia ai le tele o mea aoga aoga / meaʻai mo le PCa ma faʻatapulaʻa ai le tele o mea leaga / meaʻai leaga.
Faʻatonuga i le Lumanaʻi Mo Tofotofoga Faʻataʻitaʻi
Faʻavae i luga o le tele o faʻamaʻi, faʻataʻitaʻiga ma faʻataʻitaʻi faʻataʻitaʻiga faʻamatalaina i lenei iloiloga, meaʻai faʻavaitaimi mo le puipuia ma le togafitia o PCa taofia folafolaga sili. I se faʻaopopoga, tele meaʻai meaʻai ma vitamini / faʻaopopoga ono fesoʻotaʻi ma PCa lamatiaga ma / poʻo le alualu i luma o faʻamaʻi. Fuafuaina faʻasolosolo faʻataʻitaʻiga tofotofoga o loʻo faʻailoa manino mai e faʻamaonia ni meaʻai faapitoa poʻo ni tuʻufaʻatasi togafitiga mo le puipuia ma togafitiga o PCa.
Talu ai nei, o le mataʻituina mataʻupu (AS) na aliaʻe mai o se talafeagai filifiliga mo tamaloloa ma maualalo lamatiaga PCa. O tamaloloa i luga ole AS e faʻaosofia e tausisi i meaʻai ma fesuiaʻiga o olaga [192], ma avea ai lenei vaega ma taulaʻiga lelei mo meaʻai faʻavaitaimi ma le lelei o tofotofoga o le olaga [193]. O tagata na sao mai i le PCa o e na sili atu le malosi ma lipotia le soifua maloloina i meaʻai (o lona uiga o le taumafaina o meaʻai maualalo ole gaʻo, maualalo le faʻafefeteina o meaʻai i fualaʻau ma fualaʻau) e sili atu lona lelei ile soifuaga faʻatasi ai ma le le ola, paʻaga le maloloina [194]. O le mea lea, o faʻataʻitaʻiga le faʻataʻitaʻia o faʻataʻitaʻiga e manaʻomia e fuafua ai le aotelega o taimi umi o aʻafiaga o meaʻai i lenei faitau aofaʻi. Faʻapitoa lava, o fesili taua e talanoaina i le lumanaʻi faʻataʻitaʻiga o le: 1) Mafai ai e le faʻatinoina o meaʻai ona tolopo le manaʻoga mo togafitiga i aliʻi ile AS; 2) Mafai mea ai faʻamalositino puipuia ai le toe tupu mo tamaloloa pe a maeʻa togafitiga; 3) E mafai e meaʻai ole meaʻai ona faʻatuai le alualu i luma o aliʻi e iai faʻamaʻi faifai pea, ma faʻapea, faʻatuai le manaʻoga mo togafitiga ole hormonal; 4) Mafai gaosiina meaʻai faʻaititia le faʻaititia o itu aʻafiaga o PCa togafitiga e aofia ai togafitiga o le hormonal ma fou faʻatulagaina togafitiga; ma le 5) E i ai se matafaioi mo meaʻai faʻatino ni faʻasoaga poʻo tuʻufaʻatasia ma taulaʻi togafitiga i aliʻi i hormonal togafitiga e puipuia ai le teteʻeina o le teteʻe pe a uma le tulaʻi mai o le faʻafitauli o le teteʻeina o le gasegase? Talu ai o le faʻateleina o faʻamaoniga ua faʻaalia ai o faʻaleagaina o metabolic faʻateleina tulaga lamatia mo PCa, olaga faʻagaioia faʻalautele metabolic profile o se win-win filifiliga mo PCa puipuia ma togafitiga [195,196].
Faaiuga: Prostate Kanesa
O suʻesuʻega i le lumanaʻi e manaʻomia e fuafua ai le lelei meaʻai mo PCa puipuia poʻo togafitiga. Ae ui i lea, o le tele o meaʻai ma nisi o meaʻai e tausisi i le faʻaititia o faʻamaʻi PCa poʻo le alualu i luma ma o loʻo ogatasi ma faʻatonuga o meaʻai mo Amerika [197]. Mo le fautuaina o tagata mamaʻi i meaʻai mo le muamua ma le tulaga lua PCa puipuiga, toatele talitonu ―maa maloloina soifua maloloina tutusa ma prostate maloloina. gaʻo oona ma fatu atoa, faʻaititia le aofaʻiga ma gaʻo gaʻo, faʻaitiitia ai aano kuka ma le faʻaaogaina o se aofaʻi feololo o kalosi poʻo le faʻaititia o gaʻo oona ma le autu faʻamoemoe o le mauaina ma le faʻatumauina o le soifua maloloina mamafa.
Tauvaga fiafia O tusitala fai mai latou te le tauva fiafiaga.
Sa faia e le au tusitala le P-HL ma le SF le iloiloga, o le P-HL na tusia le tusitusiga ma le SF ma le WA na faʻataʻitaʻiina ma tuʻuina mai ni faʻamatalaga taua. O tusitala uma na faitau ma faamaonia le tusitusiga mulimuli.
Faʻafetai Faʻatupeina na saunia e ala i fesoasoani 1K24CA160653 (Freedland), NIH P50CA92131 (W. Aronson). Lenei tusitusiga o le taunuʻuga o le galuega lagolagoina ma punaoa ma le faʻaaogaina o fale i le Veterans Administration Medical Center, West Los Angeles (W. Aronson).
Tusitala auiliiliga 1 Matagaluega o Faʻafomaʻi, Vaega o Nephology, Duke University Medical Center, Box 3487, Durham, NC 27710, USA. 2 Urology Vaega, Matagaluega o taotoga, Fitafita tuai Mataupu Sili atu Los Angeles Soifua Maloloina System, Los Angeles, CA, USA. 3 Matagaluega o Urology, UCLA Aʻoga o Faʻafomai, Los Angeles, CA, USA. 4 Urology Vaega, Matagaluega o taotoga, Durham Veterans Affairs Medical Center, Vaega o Urology, Durham, NC, USA. 5 Duke Prostate Center, Matagaluega o taotoga ma togafitiga, Duke University Medical Center, Durham, NC, USA.
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O faʻamatalaga o loʻo i luga "Kanesa ole Prostate, Meaʻai Ma Meaʻai mo Meaʻai"E le o fa'amoemoe e sui ai se mafutaga ta'ito'atasi ma se fa'apolofesa fa'alesoifua maloloina agava'a po'o se foma'i laiseneina ma e le o se fautuaga fa'afoma'i. Matou te fa'amalosia oe e fai fa'ai'uga fa'alesoifua maloloina e fa'atatau i au su'esu'ega ma faiga fa'apaaga ma se tagata tomai fa'apitoa tau soifua maloloina.
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