Fa'afoma'i Fa'afouina: Su'esu'eina o Fa'amanuiaga & Tulaga lamatia

I aso nei, o tagata taʻitoʻatasi e taumafai e aloese mai taotoga e tele atu togafitiga. E mafai e vailaʻau faʻafouina ona fesoasoani e togafitia manuʻa neuromusculoskeletal?

Faʻaaogā Faʻamālōlō

O vaila'au fa'afouina e fa'aogaina ai sela mata o le tino ma fa'aaogaina i togafitiga o le kanesa ma fa'aitiitia ai le fa'ama'i pipisi. (American Cancer Society. 2020) O loo suʻe e tagata suʻesuʻe isi auala e faaaogā ai nei sela i togafitiga faafomaʻi.

O a nei Cells

• Stem cell o sela e le faʻapitoa e mafai ona atiaʻe i soʻo se sela ma i nisi tulaga e faʻafouina i latou i se numera e le faʻatapulaʻaina. (National Institutes of Health. 2016)
• O nei sela e maua i embryos ma sela matutua.
• E lua ituaiga o sela – pluripotent ma somatic. (National Institutes of Health. 2016)
• O nei sela e mafai ona liua ma avea ma so o se sela i totonu o le tino.
• O sela somatic po'o sela matua matutua e mafai ona fai aano po'o se okeni atoa. (National Institutes of Health. 2016)

faʻamālōlō

Regenerative cell therapy e faʻaaogaina nei sela e fai ma togafitiga mo se faʻamaʻi poʻo se tulaga.

• O sela toe fa'afouina e tu'uina atu i tagata ta'ito'atasi e sui ai sela ua fa'aumatia pe ua oti.
• I le tulaga o le kanesa, e mafai ona faʻaaogaina e fesoasoani ai i le tino e toe maua le malosi e gaosia ai sela toe faʻafouina pe a uma togafitiga. (American Cancer Society. 2020)
• Mo tagata taʻitoʻatasi e tele le myeloma ma nisi ituaiga o leukemia, e faʻaaogaina le togafitiga faʻafouina e faʻaumatia ai sela o le kanesa.
• Ua ta'ua le togafitiga fa'alavelave fa'asagatau-tumo/GvT, lea o lo'o fa'aogaina ai sela pa'epa'e a le tagata foa'i/WBC e fa'ate'a ai le tuma kanesa. (American Cancer Society. 2020)

O Mea e Mafai ona Latou Taulimaina

O se togafitiga fou lea o loʻo faʻaauau pea suʻesuʻega. Ua fa'amaonia e le Food and Drug Administration mo nisi kanesa ma tulaga e a'afia ai le toto ma le puipuiga. (Nofoaga Autu mo Fa'ama'i ma Puipuiga. 2019) Toe fa'afo'isia sela fa'afoma'i e fa'amaonia e le FDA e togafitia: (National Cancer Institute. 2015)

• Leukemia
• Lymphoma
• Umiloma tele
• Neuroblastoma
• E fa'aaogaina fo'i e fa'aitiitia ai le lamatiaga o fa'ama'i pe a mae'a le toe fa'afouina o sela toto i tagata ta'ito'atasi e maua i le kanesa toto. (US Food & Drug Administration. 2023)

O loʻo suʻesuʻeina e le au suʻesuʻe le auala e mafai ai e nei sela ona togafitia isi tulaga. O suʻesuʻega faʻapitoa o loʻo suʻesuʻeina pe faʻapefea ona faʻaogaina le togafitiga mo faʻamaʻi neurodegenerative pei o:

• Parkinson's
• Alzheimer's
• Tele sclerosis – MS
• Amiotrophic lateral sclerosis – ALS. (Riham Mohamed Aly. 2020)

Ituaiga Cell

I le taimi e toe fa'afo'isia ai sela, e tu'uina atu sela e ala i se laina tui. O nofoaga e tolu e mafai ona maua ai sela e fai ai le toto, o le gaʻo o ponaivi, o le umbilical cord, ma le toto. Lisi e mafai ona aofia ai: (American Cancer Society. 2020)

Autologous

• O sela e ave mai le tagata o le a mauaina le togafitiga.

Allogeneic

• O sela e foaʻi mai e se isi tagata.

Syngeneic

• O sela e sau mai se masaga tutusa, pe afai e tasi.

saogalēmū

O le togafitiga ua faʻaalia e maua ai faʻamanuiaga ae e iai aʻafiaga.

• O le tasi tulaga lamatia ua ta'ua o faʻamaʻi faʻamaʻi - GVHD.
• E tupu i le tasi vaetolu i le afa o tagata e mauaina allogeneic.
• O i'inei e le iloa ai e le tino sela pa'epa'e a le tagata foa'i ma osofa'ia ai e mafua ai fa'afitauli ma fa'ailoga i le tino atoa.
• Mo le togafitia o vailaʻau GVHD e tuʻuina atu e taofia ai le puipuiga o le tino e taofi le osofaʻia o sela foaʻi. (American Cancer Society. 2020)

O isi tulaga lamatia e mafai ona aofia ai: (American Cancer Society. 2020)

• Ua toe maua le kanesa
• Kanesa fou
• Fa'ama'i veno-occlusive ate
• Ma'i lymphoproliferative pe a mae'a fa'aliliu - PTLD

Avanoa lumanai

O le lumanaʻi o togafitiga faʻafouga faʻafouga e faʻamoemoeina. O loʻo faʻaauau pea suʻesuʻega e suʻe pe faʻafefea ona togafitia e nei sela ia tulaga ma saili ni auala fou e togafitia ma togafitia ai faʻamaʻi.
O vailaʻau faʻafouina ua suʻesuʻeina mo le silia ma le luasefulu tausaga mo tulaga e pei o le macular degeneration, glaucoma, stroke, ma le faʻamaʻi o le Alzheimer. (National Institutes of Health. 2022) O lenei togafitiga o se togafitiga faafomaʻi fou e mafai ona faʻaaogaina i togafitiga i le lumanaʻi o se vaega o a auala e tele a'oa'oga i manu'a neuromusculoskeletal ma tulaga.

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Fa'agasolo Fa'atosinaina o Tagata ma'i

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mau faasino

American Cancer Society. (2020). E fa'apefea ona fa'aogaina le su'iina o ga'o ma ponaivi e togafitia ai le kanesa.

National Institutes of Health. (2016). Fuafuaga autu.

Nofoaga Autu mo Fa'ama'i ma Puipuiga. (2019). Stem cell ma oloa fa'aola.

National Cancer Institute. (2015). Fua'au toto toto i togafitiga o le kanesa.

US Food & Drug Administration. (2023). Ua faamaonia e le FDA le togafitiga o sela mo tagata mamaʻi e maua i le kanesa o le toto e faaitiitia ai le lamatiaga o siama pe a maeʻa le totoina o sela.

Aly RM (2020). Tulaga o lo'o i ai nei o togafitiga fa'avae sela: o se va'aiga lautele. Su'esu'ega o sela, 7, 8. doi.org/10.21037/sci-2020-001

American Cancer Society. (2020). O a'afiaga e sui a'i le stem cell po'o le ga'o ponaivi.

National Institutes of Health. (2022). Le tu'uina o togafitiga fa'avae i totonu ole si'osi'omaga.