E Mafai Ona Suia Lau Epigenetic Clock?

O le matua o se natura o le olaga ma e le mafai ona taofia. Poʻo le mea sili, o le mea lena sa masani ona tatou mafaufauina. Ua talitonu le au suʻesuʻe ile Intervene Immune, Stanford, le Iunivesite o British Columbia, ma le UCLA, e mafai ona suia le tatou uati epigenetic, ma e iai foʻi auala e mafai ai ona ola umi tagata. I le mataupu o loʻo sosoʻo mai, o le a tatou talanoaina ai mea na maua e fesoʻotaʻi ma epigenetics ma le matua.

O le a le Epigenetic Clock?

O le epigenetic uati o se fua faʻatatau o tausaga matua o mea e mafai ona faʻaogaina e faʻatatau ai le matua faʻasologa o tagata poʻo isi meaola e ala i le suʻesuʻeina o le tele o mamanu o le DNA methylation. E ui lava o le matua fuafuaina e le epigenetic uati masani fegalegaleai ma chronological tausaga, e le malamalama atoatoa pe a fai o le DNA methylation talaaga i le epigenetic uati e fesootaʻi tonu ma le matua.

Mo le tele o tausaga, sa maitauina e le au suʻesuʻe suiga o le faʻatulagaina o tausaga ma le DNA methylation. Ae ui i lea, o le manatu o le faʻaaogaina o le "epigenetic clock" ina ia mafai ai ona fuafuaina le faʻasologa o tausaga e ala i le faʻataʻitaʻia o ni mamanu o DNA methylation na muamua faʻatuina e Steve Horvath lea na maua ai le taʻutaʻua ina ua maeʻa lana suʻesuʻega suʻesuʻega 2013 i le tusi o talaaga Genome Biology.

O le epigenetic uati e faʻaogaina i suʻesuʻega mo le faʻamatalaina o le matua o se tagata e le mailoa e ala i le toto poʻo isi faʻataʻitaʻiga o mea i le nofoaga o loʻo tupu ai se soligatulafono ma faʻailoga suʻesuʻe e iloa ai le tele o faʻafitauli mo maʻi e fesoʻotaʻi ma le matua, e aofia ai le tele o kanesa. O epigenetic uati e mafai foi ona faʻamamafa pe pe tele ni amioga poʻo ni togafitiga e mafai ona aʻafia ai le epigenetic tausaga.

E fetaui lelei le Epigenetic Age ma Chronological Age?

O le mafuaaga autu e epigenetic uati ma DNA methylation faʻaaogaina e fuafua ai le faʻasologa o tausaga o tagata poʻo isi meaola o loʻo latou fesoʻotaʻi lelei ma le faʻasologa o tausaga i mataupu suesueina. Le uluaʻi suʻesuʻega suʻesuʻega i luga o le epigenetic clock lea na faʻasalalau e Steve Horvath i le 2013 aofia ai 353 tagata CpG nofoaga na faʻailoa mai i isi suʻesuʻega muamua.

O nei nofoaga, 193 avea ma sili methylated ma tausaga ma 160 avea itiiti methylated, lea e tau atu ai i le DNA methylation tausaga fuafuaina e faaaoga e iloa ai le epigenetic uati. I le alualu i luma o fua uma na aʻafia ai, e aofia ai tausaga uma o mataʻupu, Horvath matauina se 0.96 fesoʻotaʻiga i le va o le epigenetic tausaga na ia fuafuaina ma le moni faʻasologa o tausaga, ma se mea sese o 3.6 tausaga.

O loʻo fai foi suʻesuʻega o uati epigenetic e fesoasoani e faʻaleleia atili ai le iʻuga o le matua faʻapea foi ma le faʻailoga ma / poʻo le tomai faʻapitoa o nei suʻega. O isi suʻesuʻega e faʻaaoga ai auala a le NGS o loʻo i ai le agavaʻa e faʻaleleia ai le epigenetic uati, ma atili ai ona faʻalautele ia latou ala i le faʻalauteleina o le suʻesuʻega o nofoaga o methylation o DNA i nofoaga uma o le CpG i le genom.

Mafai e Suia O Tatou Epigenetic Uati?

Suesuega suʻesuʻega ua faʻaalia ai o le kanesa e mafai ona suia le epigenetic uati. O nei matauga fautua mai o le epigenetic uati mafai ona suia i lalo o nisi tulaga. O lea, e mafai e le epigenetic uati e mafai ona faʻaogaina e ala i suiga i amioga poʻo togafiti togafiti e faʻagesegese ai i lalo pe ono toe faʻafoi, faʻatagaina tagata e ola umi ma ola maloloina.

E talitonu tagata suʻesuʻe e mafai ona suia a tatou uati epigenetic. I le mataupu na sosoo ai, na matou talanoaina ai mea na maua e fesoʻotaʻi ma epigenetics ma le matua. O le uati epigenetic ose fua ole tausaga olaola lea e mafai ona fa'aoga e fa'atatau ai le fa'asologa o tausaga o tagata po'o isi meaola e ala i le su'eina o le tele o mamanu ole DNA methylation. O le mafua'aga autu e fa'aoga ai uati epigenetic ma le DNA methylation e fa'atatau ai le fa'asologa o tausaga o tagata po'o isi meaola ona e fetaui lelei ma le fa'asologa o tausaga i mataupu su'esu'e. O lo'o su'esu'eina fo'i uati epigenetic o lo'o iai nei e fesoasoani atili i le fa'aleleia atili o le va'aiga o tausaga fa'apea fo'i le fa'ata'ita'iga ma/po'o le fa'ata'ita'iga o nei su'ega. O su'esu'ega su'esu'ega ua fa'aalia ai e mafai e le kanesa ona suia le uati epigenetic. O le mea lea, e mafai ona faʻaogaina le uati epigenetic e ala i suiga i amioga poʻo togafiti togafitiga e faʻagesegese ai pe mafai ona toe faʻaaogaina, faʻatagaina tagata e ola umi ma soifua maloloina. E ala i le suia o tatou uati epigenetic, e mafai foi e fomaʻi soifua maloloina ona faʻatonutonu mataupu tau soifua maloloina e fesoʻotaʻi ma tausaga, e pei ole fula ma tiga faʻatasi. O nei mea e ono mafai ona fesoasoani mo togafitiga faʻamaʻi, o se isi togafitiga e faʻaogaina ai fetuunaiga o le ivi e toe faʻaleleia ai ma le faʻaeteete le faʻaogaina o le tui.�- Dr. Alex Jimenez DC, CCST Insight

Faʻasalaga o le Zesty Beet

Auaunaga: 1
Cook taimi: 5-10 minute

1 grapefruit, peeled ma fasi
1 apu, fufulu ma fasi
1 atoa le pīti, ma ona lau peʻa iai ia oe, mulumulu ma fasi
1 XNUMX-inisi le faʻamau o le faʻaopoopo, fufuluina, fofo ma tata

Le sua o mea uma ile sua maualuga. Sili tautua.

Naʻo le tasi le kapisi e te maua uma ai meaʻai o lou vitamini i aso uma

Ioe, 'ai na'o le tasi kāloti 80g (2'oz) ua kuka e maua ai le beta carotene mo lou tino e gaosia ai le 1,480 micrograms (mcg) o vaitamini A (e mana'omia mo le fa'afouina o sela pa'u). E sili atu lena nai lo le fa'atonuina o vaitamini A i aso uma i le Iunaite Setete, e tusa ma le 900mcg. E sili le 'ai o kāloti ua vela, aua e fa'amaluluina puipui o sela e mafai ai ona fa'asusu le tele o le beta-carotene. O le fa'aopoopoina o mea'ai maloloina i au mea'ai ose auala sili lea e fa'aleleia atili ai lou soifua maloloina.

O le lautele o a matou faʻamatalaga e faʻatapulaʻaina i le fomaʻi, musculoskeletal, faʻamalositino vailaʻau, soifua maloloina, ma maaleale soifua maloloina mataupu ma / pe faʻatino vailaʻau tala, mataupu, ma talanoaga. Matou te faʻaaogaina le soifua maloloina ma le soifua maloloina faʻataʻitaʻiga e togafitia ma lagolago ai le tausiga mo manuʻa poʻo faʻaletonu o le musculoskeletal system. O a matou pou, mataupu, mataupu, ma malamalamaaga e aofia ai mataupu tau falemaʻi, mataupu, ma mataupu e fesoʻotaʻi ma lagolago tuusao pe le tuusao foi i le matou tulaga lautele o le poto masani. * Na faia e le matou ofisa se taumafaiga talafeagai e tuʻuina atu lagolago lagolago ma ua faʻailoa mai le talafeagai suʻesuʻega suʻesuʻega poʻo suesuega lagolagoina tatou pou. Matou te faia foi kopi o lagolago suʻesuʻe suʻesuʻega avanoa i le laupapa ma pe lautele pe a talosagaina. Matou te malamalama o matou aofia ai mataupu e manaʻomia se faʻaopopo faʻamatalaga i le auala e ono fesoasoani ai i se faʻapitoa tausiga fuafuaga poʻo togafitiga togafitiga; o le mea lea, ia toe talanoaina le mataupu mataupu i luga, faʻamolemole lagona saoloto e fesili ia Dr.Alex Jimenez pe faʻafesoʻotaʻi mai matou i 915-850-0900. Le laiseneina (s) Laiseneina i Texas * & New Mexico *

Faʻatonutonuina e Dr. Alex Jimenez DC, CCST

mau:

• Gaoioiga Motif Aufaigaluega. �E mafai moni ona e toe fa'afo'isia lou tausaga epigenetic?� Motugaafa Malosi, 1 Oct. 2019, www.activemotif.com/blog-reversing-epigenetic-age#:~:text=Epigenetic%20clocks%20are%20a%20measure,certain%20patterns%20of%20DNA%20methylation.
• Pal, Sangita, ma Jessica K Tyler. �Epigenetics ma le matua.� Saienitisi Maualuga, American Association for the Advancement of Science, 29 Iulai 2016, www.ncbi.nlm.nih.gov/pmc/articles/PMC4966880/.
• Matloff, Ellen. �Mirror, Mirror, On The Wall: The Epigenetics of Aging.� Forbes, Forbes Magazine, 25 Ian. 2020, www.forbes.com/sites/ellenmatloff/2020/01/24/mirror-mirror-on-the-wall-the-epigenetics-of-aging/#75af95734033.
• Dowden, Angela. 'Kofe o se Fua ma Isi Le talitonuina Meaʻai Moni Moni.' MSN Soifua Maloloina, 4 Iuni 2020, www.msn.com/en-us/foodanddrink/did-you-know/coffee-is-a-fruit-and-other-unbelievably-true-food-facts/ss-BB152Q5q?li=BBnb7Kz&ocid =mailsignout#image=24.