Janus Kinase Inhibitors Mo Togafitiga Ankylosing Spondylitis

Tagata taʻitoʻatasi ma akylosing spondylitis ia i ai se filifiliga fou togafitiga na muamua faʻaogaina mo rheumatoid gugu. O se vailaʻau e auai i se vasega lauiloa o JAK taofi Ankylosing spondylitis tuʻufaʻatasia tiga soʻoga ma le faʻaititia o feoaiga. Ankylosing spondylitis e ese aua i matuia tulaga, o ponaivi i le tuasivi mafai fuse faatasi, matua faʻaititia le feagai.   le e masani lava ona amata faʻamaʻi i le tiga ma le maʻa i tua. Lenei e masani lava a maeʻa sina taimi o le le toe toaga. Faʻailoga amata i luma o le tausaga o le 45 ma tuputupu malie. E leai se fofo mo ankylosing spondylitis ae e iai togafitiga e mafai ona faʻaleleia atili ai faʻailoga ma tuʻu ai le tulaga i le faʻamagaloga. Ankylosing spondylitis togafitiga e sili ona alualu i luma pe a fai vave fai ae le i toe faʻafoʻi le faʻaleagaina o soʻoga amata.  

Janus Kinase Inhibitors

Janus kinase inhibitors na masani ona faʻaaoga e togafitia ai:

• gugu Rheumatoid
• Psoriatic gasegase
• Ulcerative colitis

O vailaʻau e aoga ile faʻaititia ole puipuiga ole tino. O vailaʻau taofi o le Janus kinase inhibitor e aʻafia ai le tele o sela o loʻo taua i le atinaʻeina ma le alualu i luma o le ankylosing spondylitis. I le taimi nei, e naʻo le tolu Janus kinase taofiofia vailaʻau o loʻo avanoa i le Iunaite Setete ma ua faʻamaonia e le FDA e togafitia ai le rheumatoid gugu:

• Xeljanz
• Rinvoq
• Olumiant
• Ua faamaonia uma mea faʻatosina faʻatutuina faʻapitoa enzymes

Togafitiga Ankylosing Spondylitis i le taimi nei

Janus kinase taofi e le tuʻuina atu i tagata taʻitasi i le taimi lava. Peitai, e mafai ona avea ma se filifiliga pe a fai o le muamua ma le laina lona lua togafitiga e le ola. Togafitiga masani lava ona aofia ai:

Togafitiga Muamua

 

NSAIDs

Vailaau e teteʻe ai le mafaufau i le Nonsteroidal e masani ona faʻaaoga e togafitia ai fulafula ankylosing, tiga, ma le maʻaʻa.

Faʻafefete

Ole togafitiga ole faʻamalositino ole togafitiga ole vaega ole vaega ole ankylosing spondylitis togafitiga e tumau ai le fetuʻunaʻi ole tuasivi ma soifua maloloina pe a mafai. A togafiti / faʻamalositino togafitiga 'au tisaini ma atiaʻe faʻapitoa faʻamalositino e ofi ai manaʻoga taʻitasi, e aofia ai:

• Faʻaloaloa ma Faʻavaʻaiga-o-taga faʻataʻitaʻi fesoasoani faʻatumauina fetuʻunaʻi i soʻoga
• Moe ma savali savali faʻalelei taga
• Faʻamalositino ma faʻamalositino faʻamalositino faʻamalositino e tausisi i se maloloina tulaga
• Malosi malosi

Togafitiga Lona Lua

If vailaʻau e le faʻafefeteina faʻafefete aua le faʻamamaina auga, ona vailaʻau e mafai ona faatonuina. Lenei vasega o vailaʻau aofia ai:

• Tumau necrosis mea poloka poloka
• Interleukin-17 taofi

Tumor Necrosis Vaega

Tumor nekrosis factor blockers e galue i le faʻatutuina o le cell protein o se vaega o le immune system, e taʻua o tumo nekrosis alpha. O lenei polotini mafua ai mumu i le tino, ma poloka poloka taofi ia.  

Interleukin 17 Inhibitors

Interleukin 17 i le tino o le tino puipuia mai le faʻamaʻi. E faʻaaogaina le tali atu faʻafitauli e tau ai faʻamaʻi. O le taofiofi IL-17 taofiofi le tali faʻafuaseʻi ma fesoasoani faʻaititia faʻailoga.  

Isi Filifiliga Togafitiga

 

Fetuunaiga o le olaga

O le mulimuli i se togafitiga togafitiga e masani ona tuʻufaʻatasia ma meaʻai ma mea e ola ai e fautuaina e fesoasoani i le tulaga, aofia ai:

• Faʻamalosi tino pe a mafaia o le a fesoasoani:

1. Faʻaleleia / tumau se tulaga maloloina
2. Faʻaauauina le fetuunaiga
3. Faʻamafanafana tiga

• Faʻaaoga le vevela ma le aisa o le a fesoasoani faʻaitiitia:

1. tiga
2. malolo
3. Sogi

• Faataitai faamalositino

Togafitiga

Tele tagata taʻitoʻatasi ma ankylosing spondylitis e le manaʻomia se taotoga. Peitai, e mafai e se fomaʻi ona fautuaina le taotoga pe a fai e iai faʻaleagaina soʻoga, o le suilapalapa manaʻomia e sui, pe afai o le tiga e ogaoga.  

Malosiaga Faʻafefe

O loʻo faʻaauau suʻesuʻega ile togafitia ole ankylosing spondylitis. O le vailaʻau o loʻo i ai nei i le Vaega 3 faʻataʻitaʻiga mo togafitiga o tagata matutua. O faʻaiʻuga o le faʻamasinoga na faʻaalia ai o tagata mamaʻi na maua le faʻamalieina o le spylylitis spylylitis na faʻaleleia atili i

• Vaivai
• pupuga
• Paʻu tua

O le suʻesuʻega na lesitalaina ai tagata matutua o loʻo galulue faʻamalosiʻau i le spondylitis o loʻo aveina a itiiti mai e lua NSAID e le aoga i le togafitia o faʻailoga. Ole toʻatele o tagata na aʻafia o aliʻi, o le averesi o tausaga ole 41, ma e leai se faʻaogaina muamua ole faʻamaʻi o le biologic e suia ai vailaʻau ole antirheumatic.

Janus kinase mafai ona avea ma masani togafitiga

E le lava suʻesuʻega e faia ai se valoʻaga, ae o faʻamatalaga e mautinoa. O mea taofi e foliga mai o se filifiliga saogalemu pe a faʻaaogaina i se lelei suʻesuʻega, fetaui lelei tulaga e aofia ai le siakiina masani. O mea taofi e foliga mai e aoga ma maua ai le lelei o le tautala tuʻuina ma galue vave.

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Tino Faʻatasia

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Osteoarthritis ma leiloa leiloa

O le puta tele ua faʻaalia o se maualuga tulaga lamatia mo le atinaʻe o osteoarthritis. O lenei e le gata mai i aʻafiaga o le faʻaopoopo mamafa i luga o soʻoga o le tino ae o se iuga o le afaina ai aafiaga o adiposeʻaʻa. O le pito i lalo, suilapalapa, ma tulivae, e maua ai le tele o le tino mamafa. O le sili atu aofaʻi o adipose pepa solo luga o le tino ogatotonu ma vae ua faʻaalia e le lelei aʻafia le mamafa soʻoga o sooga. Faʻalauiloa Lean Body Mass ma faʻamalosia le paʻu paʻu e tuʻuina ai le aʻafiaga o le osteoarthritis ma faʻaleleia le lelei o le olaga o le tagata. O le faʻamalositino e taua tele mo tagata taʻitoʻatasi e maua i le osteoarthritis ma e tatau ona tuʻufaʻatasia e faʻaleleia atili ai le tino, faʻaititia le Tino gaʻo tele, faʻaleleia atili le Lean Body Mass ma tumau i se maloloina maloloina.  

Dr. Alex Jimenez's Blog Post Tuuese

O le lautele o a matou faʻamatalaga e faʻatapulaʻaina i le fomaʻi, musculoskeletal, faʻamalositino vailaʻau, soifua maloloina, ma maaleale soifua maloloina mataupu ma / pe faʻatino vailaʻau tala, mataupu, ma talanoaga. Matou te faʻaaogaina le soifua maloloina ma le soifua maloloina faʻataʻitaʻiga e togafitia ma lagolago ai le tausiga mo manuʻa poʻo faʻaletonu o le musculoskeletal system. O a matou pou, mataupu, mataupu, ma malamalamaaga e aofia ai mataupu tau falemaʻi, mataupu ma mataupu e fesoʻotaʻi ma lagolago tuusao pe le tuʻusaʻo ia tatou falemaʻi lautele o galuega. * Ua faia e le matou ofisa se taumafaiga talafeagai e tuʻuina atu lagolago lagolago ma ua faʻailoa mai le talafeagai suʻesuʻega suʻesuʻega poʻo suʻesuʻega e lagolagoina a matou pou. Matou te faia foi kopi o lagolago suʻesuʻe suʻesuʻega avanoa i le laupapa ma pe lautele pe a talosagaina. Matou te malamalama o matou aofia ai mataupu e manaʻomia se faʻaopopo faʻamatalaga i le auala e ono fesoasoani ai i se faʻapitoa tausiga fuafuaga poʻo togafitiga togafitiga; o le mea lea, ia toe talanoaina le mataupu mataupu i luga, faʻamolemole lagona saoloto e fesili ia Dr. Alex Jimenez pe faʻafesoʻotaʻi mai i matou i le 915-850-0900. Le laisene (s) Laiseneina i Texas & New Mexico *  

mau faasino

Hammitzsch A, Lorenz G, Moog P. Aafiaga o Janus Kinase Inhibition i le Togafitiga o Axial Spondyloarthropathies. Tuaʻiga i Immunology 11: 2488, Oketopa 2020; fai 10.3389 / fimmu.2020.591176. www.frontiersin.org/article/10.3389/fimmu.2020.591176, faʻaaogaina Ian 21, 2021. van der Heijde D, Baraliakos X, Gensler LS, et al. Malosiaga ma le saogalemu o filgotinib, o le filifilia Janus kinase 1 taofi, i tagata mamaʻi ma ankylosing spondylitis (TORTUGA): iuga mai le soʻoga, placebo-faʻatonutonuina, vaega 2 faʻataʻitaʻiga.Lancet.2018 Tes 1; 392 (10162): 2378-2387. faia: 10.1016 / S0140-6736 (18) 32463-2. Epub 2018 Oketopa 22 PMID: 30360970pubmed.ncbi.nlm.nih.gov/30360970/Cess faʻaaogaina Jan 19, 2021.